Corning Matrigel matrix is a reconstituted basement membrane preparation that is extracted from the Engelbreth-Holm-Swarm (EHS) mouse sarcoma, a tumor rich in extracellular matrix proteins.
- LDEV-free, Phenol red-free; 10mL/vial, 1/cs
- Each lot is measured for its elastic modulus, indicative of matrix stiffness that supports an organoid workflow
- Each lot is qualified to form stable "3D domes" in which organoids are typically grown
- Demonstrated to successfully grow organoids from both healthy and diseased cell origins
Organoids have become increasingly popular in disease modeling and drug discovery as they resemble the composition and functionality of organs. Extracellular matrix (ECM) is an important component of the cell niche that provides biochemical cues and structural support, such as porosity and stiffness which mediates signaling for cell migration, cell behavior and polarization in organoid structures.
Organoids support advancements in the study of organogenesis, disease modeling, and subsequently patient-specific therapies. Stem cells and/or organ progenitors from normal or diseased tissue are mixed with Corning Matrigel matrix to create miniorgans of the kidney, thyroid, liver, brain, lung, intestine, prostate, pancreas, breast, esophagus, and ovary. Corning Matrigel matrix is the most published hydrogel for organoid research due to its close resemblance to an in vivo environment, providing necessary growth factors, proteins, and the required matrix architecture.