Tris(hydroxymethyl)aminomethane (TRIS, Trometamol)

Supplier: MP Biomedicals

Synonyms: Tris (Hydroxymethyl) AminomethaneTrometamol2-Amino-2-(hydroxymethyl)propane-1,3-diol

ICNA0219485594EA 1108 EUR
ICNA0219485594 ICNA0219485583 ICNA0219485590 ICNA0219485591 ICNA0219485580
Tris(hydroxymethyl)aminomethane (TRIS, Trometamol)
Tris(hydroxymethyl)aminomethane (TRIS, Trometamol)

Tris has been useful as buffers in a wide variety of biological systems. Uses include pH control in vitro and in vivo for body fluids and in buffering systems for electrophoresis applications. Tris has been used as a starting material for polymers, oxazolones (with carboxylic acids) and oxazolidines (with aldehydes). Tris does not precipitate calcium salts and is of value in maintaining solubility of manganese salts. It can be used for the direct standardization of a strong acid solution; the equivalence point can be determined either potentiometrically or by use of a suitable indicator such as 3-(4-Dimethylamino-1-naphthylazo)-4-methoxybenzenesulfonic acid. It is an auxiliary material in pharmaceutical science.
Store at Room Temperature (15-30 °C). Store dessicated.


  • Molecular Biology Reagent Grade
  • Vapor Pressure: Low at ambient temperatures.(lit.)
  • Presentation: White Crystalline Powder
  • pKa: 8.1 at 25 °C(Lit.)

Formula: NH₂C(CH₂OH)₃
MW: 121,14 g/mol
Boiling Pt: 219…220 °C (10 mmHg)) (lit.)
Melting Pt: 167…172 °C
MDL Number: MFCD00004679
CAS Number: 77-86-1
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Specification Test Results

Identity Test Passes
Purity ≥99.95%
FTIR Conforms to Standard
pH (5% aq soln) 10-11.5
OD 260 nm (5% aq soln) ≤0.1
Loss on Drying ≤1%
Solubility (40% aq soln) Clear, Colorless Solution

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