Anti-CASP8 Rat Monoclonal Antibody [clone: 3B10]

Supplier: ProSci
PRSI36-181EA 525 EUR
PRSI36-181
Anti-CASP8 Rat Monoclonal Antibody [clone: 3B10]
Antibodies
Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. At the first cleavage step, the N-terminal p43/p41 and the C-terminal p30 cleavage products are generated. Importantly, these cleavage products already possess catalytic activity. At the second cleavage step, p43/p41 and p30 are processed to p10 and p20, respectively, which leads to the generation of the active caspase-8 heterotetramer (p20/p10)2.

ELISA: (recombinant protein) . Flow Cytometry: (overexpressed in cell lines) . Immunocytochemistry: (excellent, see literature reference 2). Immunohistochemistry Western Blot: (1-2ug/ml) . Optimal conditions must be determined individually for each application.

Type: Primary
Antigen: CASP8
Clonality: Monoclonal
Clone: 3B10
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG1 kappa
Reactivity: Mouse
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