Thy-1 membrane glycoprotein(THY1)is a 141 amino acids protein that contains 1 Ig-like V-type domain. Thy-1 is a 25–37 kDa heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte antigen. Thy-1 can be used as a marker for a variety of stem cells and for the axonal processes of mature neurons. Structural study of Thy-1 lead to the foundation of the Immunoglobulin superfamily, of which it is the smallest member, and led to some of the initial biochemical description and characterisation of a vertebrate GPI anchor and also the first demonstration of tissue specific differential glycosylation. It may play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
This recombinant protein can be used for biological assays. For research use only.