Mouse recombinant B7-H4 (from CHO cells)

Supplier: ProSci
PRSI90-371EA 584 EUR
PRSI90-371
Mouse recombinant B7-H4 (from CHO cells)
Proteins and Peptides
B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumour cancer cells. The role of B7-H4 in tumour progression may be to transform precancerous cells and then protect them from immunosurveillance.

  • This recombinant proteins is for research use only.

Fusion-Tag: Fc Tag

This recombinant proteins is for research use only.
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