The pharmacologic activity of acetylcholine (ACTH) is mediated by the ionotropic nicotinic receptor or via metabotropic muscarinic receptors. Five known acetylcholine (muscarinic) receptors (M1-M5) are variably expressed in the central nervous system and periphery, mediating motor control, thermoregulation, memory, smooth muscle contraction, glandular secretion, and cardiac function. Although the physiology of the five mammalian muscarinic receptor homologs does not differ significantly in their affinities to a variety of agonists (ACTH, muscarine) and antagonists (e.g., atropine), they can be divided into two sub-groups (M1/M3/M5 and M2/M4) based on G alpha subunit coupling preferences. M1/M3/M5 receptors signal primarily via Gq/11 alpha subunits to stimulate phospholipase C, whereas M2/M4 receptors couple to Gi/o alpha subunits to inhibit adenylyl cyclases and cAMP production. Modulation of muscarinic receptor activity holds promise for the treatment of psychiatric and neurological disorders including schizophrenia and Alzheimer's disease.
Recognizes rat muscarine receptor M1. Predicted MW of ~51kDa. Predicted species reactivity based on epitope sequence homology: human, mouse, horse, bovine, guinea pig, dog, orangutan, chimpanzee, wild boar, rhesus macaque, opossum.
For Western Blot
Ordering information: Manufactured by Proteimax.
Type: Primary
Antigen: MUSCARINIC ACETYLCHOLINE RECEPTOR M1
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: Rat