The formation of protein-cysteine adducts, or cysteinylation, is a post-translational protein modification known to modify inherent protein binding properties. Cysteinylation is known to affect the presentation of antigenic peptide epitopes on MHC molecules, regulating the immune response to tumor antigens and contributing to autoimmune diseases including type I diabetes. Cysteinylation of the potentially oncogenic protein kinase C (PKC) isozymes epsilon and gamma has been shown to regulate inactivation of their enzymatic activity, at the same time stimulating the pro-apoptotic function of PKC delta, making isozyme-specific PKC regulators an attractive target for the treatment of proliferative diseases such as cancer.
- For ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Reactivity: Species Independent