Necrox-5™ methanesulphonate

Supplier: Enzo Life Sciences

Synonyms: [5-(1,1-Dioxo-thiomorpholin-4-ylmethyl)-2-phenyl-1H-indol-7-yl]-(tetrahydro-pyran-4-ylmethyl)-amine

ALEXALX430167M001EA 259 EUR
ALEXALX430167M001 ALEXALX430167M005
Necrox-5™ methanesulphonate
Necrox-5™ methanesulphonate

Necrosis inhibitor


Cell permeable necrosis inhibitor with antioxidant activity. It localizes mostly in the mitochondria. Selectively blocks oxidative stress-induced necrotic cell death (0.1μM NecroX™-5 prevented ~50% cell death in H9C2 cells exposed to 400μM t-BuOOH for 2 hours LDH assay used). Does not protect against staurosporine or etoposide-induced apoptosis. Protects cells against cold shock, hypoxia and oxidative stress in vitro, as well as CCl4 -induced acute liver injury and chronic liver fibrosis in rodent models.

Formula: C₂₅H₃₁N₃O₃S·2CH₄O₃S
MW: 645,8 g/mol
CAS Number: 1383718-29-3
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