ZM 447439 ≥98% (by TLC)

Supplier: Enzo Life Sciences

ALEXBML-EI373-0001EA 114 EUR
ALEXBML-EI373-0001 ALEXBML-EI373-0010
ZM 447439 ≥98% (by TLC)
ZM 447439

ZM-447439 is a potent and selective inhibitor of Aurora B kinase (IC50=50nM), Aurora A and C are inhibited at higher concentrations (IC50=1000nM and 250nM respectively). Other kinases such as Cdk1 and PLK1 are not inhibited (up to 10mM). Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail.


  • Aurora kinase inhibitor


ZM-447439 is a potent and selective inhibitor of Aurora B kinase (IC50=50nM), Aurora A and C are inhibited at higher concentrations (IC50=1000nM and 250nM respectively). Other kinases such as Cdk1 and PLK1 are not inhibited (up to 10mM). Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail.


Soluble in DMSO (25 mg/ml).

Formula: C₂₉H₃₁N₅O₄
MW: 513,6 g/mol
MDL Number: MFCD08703125
CAS Number: 331771-20-1
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