ENMD-1068

Supplier: Enzo Life Sciences

ALEXBML-N110-0005EA 145 EUR
ALEXBML-N110-0005 ALEXBML-N110-0025
ENMD-1068
ENMD-1068

Proteinase-activated receptor ligand


Selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-α and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaolin-injected mouse model.

Formula: C₁₅H₂₉N₃O₂·HCl
CAS Number: 789488-77-3

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