N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide (MTBSTFA) silylation reagent, for GC derivatisation

Supplier: MACHEREY-NAGEL
Warning

MANA701440.101EA 311 EUR
MANA701440.101 MANA701440.201
N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide (MTBSTFA) silylation reagent, for GC derivatisation
N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide (MTBSTFA)

MBDSTFA is a silylation reagent that donates a tert-butyldimethylsilyl group (TBDMS) for derivatizing active hydrogen atoms in hydroxyl, carboxyl and thiol groups, primary and secondary amines as well as amino acids. Fast reactions (typically 5–20 min) with high yields (> 96 %). By-products are neutral and volatile.


  • Silylation can be applied on many compounds
  • Silylation reagents are easily prepared
  • MBDSTFA derivatisation has a fast reaction time


TBDMS ethers are 10⁴ times more stable than the corresponding TMS ethers. Chromatographic retention times are longer due to the large protecting group, which may improve some separations. Very useful for GC-MS applications, because of the high molecular ion concentration at M+-57.

Formula: C₉H₁₈F₃NOSi
MW: 241,33 g/mol
Boiling Pt: 168–170 °C (760 mm Hg)
Density: 1,121 g/cm³ (d20°/4°)
UN: 3316
ADR: 9,II

Order Now

Learn more

About VWR

Avantor is a vertically integrated, global supplier of discovery-to-delivery solutions for...

Learn more About VWR