HMDS (1,1,1,3,3,3-hexamethyldisilazane) silylation reagent, for GC derivatisation

Supplier: MACHEREY-NAGEL
Danger

MANA701240.510EA 48.7 EUR
MANA701240.510 MANA701240.650
HMDS (1,1,1,3,3,3-hexamethyldisilazane) silylation reagent, for GC derivatisation
HMDS (1,1,1,3,3,3-hexamethyldisilazane)

HMDS is weak TMS donor. If used as sole reagent, it is slow and not very effective. After addition of catalytic quantities (e.g., 1 %) of TMCS or as a mixture with TMCS it is a fast and quantitative reagent for trimethylsilylation of organic compounds.


  • Silylation can be applied on many compounds
  • Silylation reagents are easily prepared
  • HMDS reagent mixed with TMCS catalyst shows fast and quantitative reaction


Aprotic solvents like acetonitrile, pyridine, dimethylformamide, carbon disulfide and dimethylacetamide are recommended for use with HMDS.

Formula: (CH₃)₃SiNHSi(CH₃)₃
MW: 161,39 g/mol
Boiling Pt: 126 °C (760 mm Hg)
Density: 0,7742 g/cm³ (d20°/4°)
MDL Number: MFCD00008259
CAS Number: 999-97-3
UN: 3316
ADR: 9,II
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