Organic reference standard, 7alpha-Hydroxy-4-cholesten-3-one, ≥95,0% (HPLC), Supelco®

Supplier: Merck
52853-1MGEA 348 EUR
52853-1MG 52853-5MG
Organic reference standard, 7alpha-Hydroxy-4-cholesten-3-one, ≥95,0% (HPLC), Supelco®
Standards Organic Standards
7α-Hydroxy-4-cholesten-3-one (C4) is known as a marker for the cholesterol 7α-hydroxylase activity. It plays an important role in bile acid metabolism.

  • Human serum by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) with electrospray ionisation source (ESI) as well as LC-MS
  • Rat and monkey plasma by LC-ESI-MS/MS working on multiple reaction monitoring (MRM) mode of detection
  • Peripheral blood plasma by solid-phase extraction (SPE) and HPLC

7a-Hydroxycholestene-3-one, a metabolite in bile acid synthesis, is derived from 7a-hydroxycholesterol and can be further metabolised to 7a, 12a, -dihydroxycholest-4-en-3-one.

Analysis of 7a-Hydroxycholestene-3-one (HCO) in serum may serve as a novel, simple, and sensitive method for the detection of bile acid malabsorption in patients with chronic diarrhea of unknown origin.
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