Recombinant Shistosoma Mansoni Thioredoxin Glutathione Reductase

Supplier: SeLENOZYME

SELZSMTGR-50EA 3380 EUR
SELZSMTGR-50 SELZSMTGR-20 SELZSMTGR-10 SELZSMTGR-5
Recombinant Shistosoma Mansoni Thioredoxin Glutathione Reductase
Proteins and Peptides
The TGR selenoprotein of Schistosoma mansoni is the only major reductive cytosolic flavoprotein of this parasite, taking over the combined role of TrxR1 and glutathione reductase, thereby exerting a wide range of functions in redox control and antioxidant systems and being a promising drug target for treatment of schistosomiasis.
We provide the main the Schistosoma mansoni TGR enzyme with more than 90% Sec contents and more than 95% purity in aliquots at amounts from 5 to 50 units.

  • Genuine Sec-containing selenoproteins
  • No animals used as protein sources (grown in bacteria)
  • More than 90% Sec contents
  • More than 95% purity

Recombinant Shistosoma Mansoni Thioredoxin Glutathione Reductase (Non-tagged, 598 residues)

5 (10, 20, 50) Units, ca 0.25 (0.5, 1, 2.5) mg protein stored in TE buffer with 50% glycerol. Concentration 1 mg/ml.

1 U of enzyme reduces 1 μmol DTNB per min in 0.5 ml standard DTNB assay containing 2.5 mM DTNB and 0.3 mM NADPH in TE buffer (50 mM Tris-HCl, 2 mM EDTA, pH 7.5)

References: Cheng Q, Arnér ES. (2017) Selenocysteine Insertion at a Predefined UAG Codon in a Release Factor 1 (RF1)-depleted Escherichia coli Host Strain Bypasses Species Barriers in Recombinant Selenoprotein Translation. J Biol Chem. 292:5476-5487.
Arnér ES, Holmgren A. (2001) Measurement of thioredoxin and thioredoxin reductase. Curr Protoc Toxicol. Chapter 7:Unit 7.4.

Delivery information: Protein stored in TE buffer with 50% glycerol. Concentration 1 mg protein/ml. Shipped in cold pack by courier service. Store at −20 °C upon delivery.

Packaging: Aliquots

Caution: Centrifuge the tube briefly before opening the lid.
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