N,O-Bis(trimethylsilyl)trifluoroacetamide silylation reagent, for GC derivatisation

Supplier: MACHEREY-NAGEL

MANA701220.510EA 219 EUR
MANA701220.510 MANA701220.110 MANA701220.201
N,O-Bis(trimethylsilyl)trifluoroacetamide silylation reagent, for GC derivatisation
N,O-Bis(trimethylsilyl)trifluoroacetamide

BSTFA is a powerful trimethylsilyl donor with approximately the same donor strength as the nonfluorinated analog BSA. Advantage of BSTFA over BSA: greater volatility of its reaction products (particularly useful for GC of some lower boiling TMS amino acids).


  • Silylation can be applied on many compounds
  • Silylation reagents are easily prepared
  • BSTFA derivatives have great volatility


Non polar (less polar than MSTFA), and can be mixed with acetonitrile for improved solubility.


BSTFA will generally react with all organic material present, but may not react with some amides, secondary amines and hindered hydroxyl groups. However, adding of 1% TMCS as catalyst will facilitate the reaction.

Formula: C₈H₁₈F₃NOSi₂
MW: 257,4 g/mol
Boiling Pt: 40 °C (12 mm Hg)
Melting Pt: –41 °C
Density: 0,96 g/cm³ (20 °C)
Flash Pt: 34 °C
UN: 2924
ADR: 3,II

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