Bond Elut™ DEA bears some resemblance to Bond Elut™ NH₂ in its properties but with a slightly lower capacity as an anion exchange sorbent. DEA has a moderately non-polar character due to the alkyl side chains on the amino functionality. These groups still afford a medium level of polarity, higher than C₈ but less polar than C₂ or CN-E.
- More polar than C₈ but less polar than C₂ or CN
- Lower ionic capacity than NH₂
- Alkyl side chains confer moderately non-polar chracteristics
Bond Elut™ DEA is an excellent phase for the extraction of bisphosphonates from human serum and urine. Bisphosphonates are extremely hydrophilic and structurally similar to many endogenous phosphorylated compounds, making their selective extraction from serum or urine very challenging. The unique chemistry of Bond Elut™ DEA offers excellent selectivity of this class of compounds.